Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases
نویسندگان
چکیده
We establish a computational approach to extract the bending modulus, KC , for lipid membranes from relatively small-scale molecular simulations. Fluctuations in the splay of individual pairs of lipids faithfully inform on KC in multicomponent membranes over a large range of rigidities in different thermodynamic phases. Predictions are validated by experiments even where the standard spectral analysis-based methods fail. The local nature of this method potentially allows its extension to calculations of KC in protein-laden membranes.
منابع مشابه
Elastic curvature constants of lipid monolayers and bilayers.
Bending elasticity is an important property of lipid vesicles, non-lamellar lipid phases and biological membranes. Experimental values of the mean curvature moduli, k(c), of lipid bilayers and of the monolayer leaflets of inverted hexagonal (H(II)) phases of lipids are tabulated here for easy reference. Experimental estimates of the Gaussian curvature modulus, k (c), are also included. Consider...
متن کاملUndulating Charged Fluid Membranes and their Bending Constants
We consider harmonically undulating ionic surfactant membranes, calculating a general expression for the bending modulus valid for all salt and surfactant concentrations, and surface charge densities. This is achieved through a perturbative expansion of the meanfield electrostatic potential and free energy about a planar reference state, consisting of two parallel planar membranes with interven...
متن کاملElectric Field Effects in Multicomponent Fluid Lipid Membranes
A thermodynamic model of multicomponent fluid membranes under the influence of lateral forces is described. Membrane components are characterized by their effective molecular areas, molecular charges, and the set of critical demixing coefficients (differential interaction energies) between each of the different species present. This model is useful in the analysis of electric field induced conc...
متن کاملPoisson’s Ratio and Young’s Modulus of Lipid Bilayers in Different Phases
A general computational method is introduced to estimate the Poisson's ratio for membranes with small thickness. In this method, the Poisson's ratio is calculated by utilizing a rescaling of inter-particle distances in one lateral direction under periodic boundary conditions. As an example for the coarse grained lipid model introduced by Lenz and Schmid, we calculate the Poisson's ratio in the ...
متن کاملDynamics of multicomponent vesicles in a viscous fluid
We develop and investigate numerically a thermodynamically consistent model of two-dimensional multicomponent vesicles in an incompressible viscous fluid. The model is derived using an energy variation approach that accounts for different lipid surface phases, the excess energy (line energy) associated with surface phase domain boundaries, bending energy, spontaneous curvature, local inextensib...
متن کامل