Calculating the Bending Modulus for Multicomponent Lipid Membranes in Different Thermodynamic Phases

نویسندگان

  • George Khelashvili
  • Benjamin Kollmitzer
  • Peter Heftberger
  • Georg Pabst
  • Daniel Harries
چکیده

We establish a computational approach to extract the bending modulus, KC , for lipid membranes from relatively small-scale molecular simulations. Fluctuations in the splay of individual pairs of lipids faithfully inform on KC in multicomponent membranes over a large range of rigidities in different thermodynamic phases. Predictions are validated by experiments even where the standard spectral analysis-based methods fail. The local nature of this method potentially allows its extension to calculations of KC in protein-laden membranes.

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عنوان ژورنال:

دوره 9  شماره 

صفحات  -

تاریخ انتشار 2013